The World May Soon Run Out of Antibiotics

Thursday, 21 Sep, 2017

The authors have also said that numerous new drugs that are being developed are drugs which patients have already developed drug resistance to and are mostly modifications of now existing antibiotics.

According to Mario Raviglione, Director of the WHO Global Tuberculosis Programme, research for tuberculosis is seriously underfunded, with only two new antibiotics for treatment of drug-resistant tuberculosis having reached the market in over 70 years.

Resistance to antibiotic drugs is a "global health emergency" that threatens the progress made by modern medicine, the head of the UN's health agency warned as a new report was published Wednesday.

Multidrug- and extensively drug-resistant M. tuberculosis (MDR-TB) is an ever-growing threat, and, according to the press release, there is "a serious lack of treatment options" to fight it.

There is an urgent need for more investment into the research and development of antibiotic-resistant infections such as TB, says the WHO's Director-General Dr Tedros Adhanom Ghebreyesus.

Separately, the World Health Organization today also published a report entitled, "Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis".

According to World Health Organization, based on the average 7-year development time from phase 1 to approval, the current pipeline could lead to the approval of 10 antibiotics or biologicals over the next 5 years, which the agency said is insufficient to tackle the impending threat of antimicrobial resistance.

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WHO. Antibacterial agents in clinical development - an analysis of the antibacterial clinical development pipeline, including Mycobacterium tuberculosis.

However, it is not on antibiotics alone - preventing the spread of infection of these diseases is now emore important than ever.

The group is urging for more research in order to give people around the globe more options if they encounter a drug-resistant infection.

There are also very few oral antibiotics in the pipeline, yet these are essential formulations for treating infections outside hospitals or in resource-limited settings, the report said.

The report identifies 51 new antibiotics and biologicals in clinical development to treat priority antibiotic-resistant pathogens, as well as tuberculosis and the sometimes deadly diarrhoeal infection Clostridium difficile.

Despite a recent multinational initiatives like the €56m Global Antibiotic Research and Development Partnership, WHO said that new drugs will not completely solve the problem and is encouraging greater procedures for the prevention of infection. It is also developing guidance for the responsible use of antibiotics in the human, animal and agricultural sectors. And because drug development is a drawn-out process, most of it unsuccessful, current efforts could result in only about 10 new approvals in the next five years, the report said.